The gang went to the jail to pick up Brian who had been arrested. Peter told everyone to get their best anal rape jokes ready. After flopping himself, chris blurted "Hey Brian, who's you're favorite baseball player- Albert Pujols?!" As most people know his name is pronounced "Poo-holes". As a cards fan I thought it was hilarious!
Well, I don't remember what the situation was in which he made the joke, but it was obviously condescending in nature, and I suppose it was directed at Meg, as must jokes are.